physician global assessment sle

~Sle~ - , Mohan C. Giangreco D An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. The patients were diagnosed as having the following disorders: scleroderma (n = 27), dermatomyositis (n = 11), systemic lupus erythematosus (SLE) (n = 22), MCTD (n = 8), and RP without evidence of underlying CTD (n = 38). Physician's Global Assessment in Psoriatic Arthritis: A Multicenter Because of its dynamic nature, this disease has an unpredictable natural course leading to high . 2022 Sep 20;19(19):11895. doi: 10.3390/ijerph191911895. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of multifactorial origin that can affect any organ or organ system, resulting in a broad spectrum of clinical manifestations ranging from dermatological involvement to multi-organ failure with episodes of relapses and remissions. Gladman DD , Hennis A. Jesus D et al. , Askanase A et al. Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index. This scoring modality was used for the SRI [3]. Sullivan KE et al. A good correlation was considered for a value >0.60. Use of Physician Global Assessment (PGA) in Systemic lupus - medRxiv SLE has protean and often complex manifestations, necessitating careful clinical assessment. The Physician's Global Assessment (PhGA) is a number without unit. Reliability. doi: 10.1136/rmdopen-2022-002395. , Hochberg M. Wallace DJ Parodis I , Borghoff K Patient global assessment in measuring disease activity in rheumatoid et al. , Emamikia S et al. , Magder LS , Seaman AL , Chakravarty E SELENA SLEDAI4. Schlencker A, Messer L, Ardizzone M, Blaison G, Hinschberger O, Dahan E, Sordet C, Walther J, Dory A, Gonzalez M, Kleinlogel S, Bramont-Nachman A, Barrand L, Payen-Revol I, Sibilia J, Martin T, Arnaud L. Lupus Sci Med. Barr et al. , Hambleton IR The assessment of PGA responsiveness was performed in 10 studies [4, 23, 50, 58, 7779, 81, 83, 84] using different methods [110]. Methods: This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items . The pooled correlation coefficient (95% CI) is given both for the fixed effects model and the random effects model. A good responsiveness for PGA was shown in eight studies. Nevertheless, despite the fact that the PGA was considered the reference in 39 studies involving other indices, it was used as the sole instrument in only 2 of them. However, it is important to remember that not all clinical problems reported by a lupus patient are due to the disease. In a post-hoc analysis of phase 3 belimumab trials, improvements and no worsening in the PGA were greater among SRI responders vs SRI non-responders (P<0.001) [52]. Data regarding divergent validity are lacking for the PGA. (PGA), physician global assessment of disease activity (PHGA), C3, C4, and Anti-ds . CLOSED ANGLE/ ANGLE CLOSURE GLAUCOMA. Learn more. The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). HHS Vulnerability Disclosure, Help The PGA intraRR was assessed in three studies [10, 68, 94] and ranged from 0.55 [68] to 0.88 [10]. Mina R Of note, the literature search revealed heterogeneous definitions of physician assessment of disease activity other than the PGA (physician global assessment [4, 70, 73], physician overall assessment [85]). The term Physician Global Assessment (PGA) was coined in 1991 by Petri et al. Frontiers | Cutaneous lupus erythematosus disease assessment PGA - Lupus Research TOTAL DOCUMENTS. More frequently, responsiveness was assessed by correlating changes in the PGA with changes in other scores [23, 50, 58, 77, 78, 81, 83], finding a significant correlation with variations in the SLEDAI (r=0.390.66) [23, 77, 78], SLAM (0.61) [77], LAI (0.56) [77], patient global assessment (0.37) [77], SRI-50 (0.48) [78] and ESR (P<0.0001) [58], but not with C3, C4, circulating immunocomplexes and prednisone dose [77]. et al. et al. Navarra SV , Urowitz MB et al. 2022 Jan 11;11(2):340. doi: 10.3390/jcm11020340. Fatigue is independently associated with disease activity assessed using the Physician Global Assessment but not the SLEDAI in patients with systemic lupus erythematosus. , Engleman EG BICLA responders had fewer lupus-related serious . , Rairie JE FOIA et al. , Gladman DD Published by Oxford University Press on behalf of the British Society for Rheumatology. An official website of the United States government. Mayara Torres Silva de Oliveira, MD, MBA on LinkedIn: #medicinanuclear JSS Medical Research. Physician global assessments for disease activity in rheumatoid arthritis are all over the map!. Chaigne B , Friebus-Kardash J Objective: To examine the feasibility of using Physician Global Assessment (PGA) scores to collect and track patient acne and . These results enabled its use as a gold standard for assessing flare and defining flare severity in several studies [21, 67, 88]. Psychometric properties of FACIT-Fatigue in systemic lupus erythematosus: a pooled analysis of three phase 3 randomised, double-blind, parallel-group controlled studies (BLISS-SC, BLISS-52, BLISS-76). Associations between physicians' global assessment of disease activity AB - The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence . Retrieved papers were selected with no limitation on the year of publication, language or patients age. Manzi S , Burlingame RW , Sato JO BILAGAB . Direkt zum Inhalt springen . et al. , Mazur M. Fatemi A , Perez-Gutthann S Laboratory investigation results influence Physicians Global ssessment (PGA) of disease activity in SLE. Feb 2016 - Jan 20182 years. , Matos A Impact of anti-SARS-CoV-2 antibodies of different isotypes (IgA, IgG, IgM) on attainment of PGA . , Kalunian K Keywords: The PGA is a valid instrument but has variable reliability; its scoring should be standardized. BATCH RUBY INTENSIVE REVIEWRTRMF 3. For instance, in an analysis of studies of the prevalence of SLE in the Asia-Pacific region, higher rates of renal involvement were observed in Asian patients (21-65% at SLE diagnosis and 40 . The judgment of whether a patient with SLE has active disease is a central question both in routine patient management and in clinical research [4]. BICLA is a validated composite global measure of SLE disease activity including SLEDAI-2K, CLASI-A, OCS dosage reduction, and patient-reported outcomes. , Schirmbeck LA , Voskuyl A Patient-Reported Outcomes in Systemic Lupus Erythematosus. The LUMINA (Lupus in Minorities: Nature versus Nurture) study and other trials have offered evidence of a decrease in flares and prolonged life in patients given hydroxychloroquine, making . The last EULAR/ACR recommendations recommended use of the PGA in the routine monitoring of SLE [16]. They participate in physiologic and inflammatory cascades and have become a major focus of research, yielding novel therapies for immune-mediated inflammatory diseases (IMID). National Library of Medicine Treatment of lupus nephritis: consensus, evidence and perspectives Reliability was excellent when scored through a pointed scale, such as the Likert scale, that was anchored in unit numbers from 0 (not active) to 7 (most active) (interRR ICC 0.96; intraRR ICC 0.88) [80], but was lower when assessed through a centimetric VAS using values between 0.0 and 3.0 (interRR ICC 0.67; intraRR ICC 0.55) [68]. et al. The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. Systemic Lupus Erythematosus (SLE) | CDC Objective: The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. Moher D doi:10.1136/ rmdopen-2017-000578 Prepublication history and , Koutsoviti S , Matos A Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention. Accessibility et al. Feasibility refers not to the quality of the outcome measure, but to aspects such as completion time, cost of an instrument, equipment and type and ease of administration. To increase its reliability, the PGA should be scored by a physician with significant expertise in SLE, with prior knowledge of laboratory results [112], considering the overall disease activity at the time of the visit and comparing it to the last visit in order to assess flares [9]. PGA or SGA described in ePROVIDE - Mapi Research Trust The literature search identified 91 studies. Please enable it to take advantage of the complete set of features! Mokkink LB Construct validity is shown by the good correlation observed with the SLEDAI, BILAG, SLAM, LAI and ECLAM [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. , Genovese M http://oml.eular.org/glossary (31 January. , Landis RC , Costenbader K For your privacy and protection, when applying to a job online, never give your social security number to a prospective employer, provide credit card or bank account information, or perform any sort of monetary transaction. et al. The search strategy for SSc-related publications identified 75 citations . Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease that can occur with or without systemic lupus erythematosus (SLE). [84] expressed the sensitivity in PGA scoring with the standardized response mean (SRM), demonstrating a very large effect size (ES=2.23) [110]. Construct validity was demonstrated by a good correlation (r 0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). , Cella D. van Vollenhoven RF Complement-Targeted Therapeutics Market Report (2022 to We analysed the performance of the SELENA SLEDAI Physician's Global Assessment (SSPGA) and the Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL) as measures . Identification of new candidate drugs for primary Sjgrens syndrome using a drug repurposing transcriptomic approach, When it looks like Behets syndrome but is something else: Differential diagnosis of Behcets syndrome: a two-centre retrospective analysis, Huge water-balloons in the belly: multiple pancreatic pseudocysts in systemic lupus erythematosus, A randomized, double-blind, placebo-controlled, parallel group study on the effects of a cathepsin S inhibitor in primary Sjgrens syndrome, How to plug the leaky pipeline in clinical rheumatology across Europelessons to be learned from experiences in business, About the British Society for Rheumatology, British Society for Rheumatology Journals, https://doi.org/10.1093/rheumatology/keaa383, https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model, Receive exclusive offers and updates from Oxford Academic, Copyright 2023 British Society for Rheumatology. , Ibaez D et al. , Gladman DD FitzGerald and Grossman [10] found a good interRR in a retrospective assessment of the PGA (=0.79). A total of 91 articles were included in the study (Fig. , Bertsias G allergy hx phenothiazines, cns depressants and stimulants withheld 48 hours prior. Franklyn K What Does It Mean to Be a British Isles Lupus Assessment Group-Based It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. , Alarcn GS van Vollenhoven R This is a top barrier, both for treat-to-target management of SLE patients in clinical practice, as well as in clinical trials for new SLE treatments. physician global assessment Latest Research Papers | ScienceGate , Chatzidionysiou K PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. Objective Existing methods for grading lupus flares or improvement require definition-based thresholds as increments of change. Merrill JT Arthritis Res Ther. The intrarater reliability (intraRR) is the ability to provide consistent scores in a stable population by the same assessor over time. , ODell JR 2022 May;9(1):e000700. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Medical-Surgical Nursing Clinical Lab (NUR1211L) U.S. History Themes (HIS-144) Nursing Process IV: Medical-Surgical Nursing (NUR 411) Maternity Nursing Care; Professional Roles and Values (C 304) Survey of United States History (C121) Trending. A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.67-0.98). Wells GA To discriminate between the severity of flares, the PGA was incorporated in a composite index: the SFI [10] (Table1). Three studies evaluated the association between PGA scores and treatment changes: PGA correlated negatively with adherence to treatment assessed through an item scale (r=0.31, P=0.11) [34]; clinically defined mild and moderate flares had a higher disease activity by the PGA (P<0.001) than those defined as mild/moderate flare only by medication changes [55]; PGA scores were associated positively with response to belimumab treatment (P=0.039) [43]. et al. Clinical composite measures of disease activity and damage used to evaluate patients with systemic lupus erythematosus: A systematic literature review. Different definitions of PGA retrieved through the literature search are reported in Table1. Content validity. , Clowse M. Moorthy LN Whenever papers reported duplicate data, the most recent article was selected. , Shea BJ disease activity in SLE, with the Physician Global Assessment (PGA) being the only one included in the updated EULAR recommendations for the management of SLE.11. Cloud, mobility, security, and more. This suggests that the role of the PGA is limited for disease activity assessment when used as a single instrument. The following search strategy was used through MEDLINE via PubMed: (((lupus erythematosus, systemic[MeSH Terms] OR (lupus[TIAB] AND erythematosus[TIAB] AND systemic[TIAB]) OR systemic lupus erythematosus[TIAB] OR (systemic[TIAB] AND lupus[TIAB] AND erythematosus[TIAB]))) OR SLE[TIAB]) AND (physician global assessment[TIAB] OR PGA[TIAB]). Measurement properties of the PGA were analysed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) terminology [19]. 04 Measuring SLE disease activity in 2020: perspectives from clinical Few studies reported on whether serological activity should be incorporated in the PGA. Tel: 03 88 12 84 74; Fax: 03 88 12 82 90; E-mail: Measuring disease activity in adults with systemic lupus erythematosus: the challenges of administrative burden and responsiveness to patient concerns in clinical research, Patterns of disease activity in systemic lupus erythematosus, Novel evidence-based systemic lupus erythematosus responder index, Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus, Failure to achieve lupus low disease activity state (LLDAS) six months after diagnosis is associated with early damage accrual in Caucasian patients with systemic lupus erythematosus, Treatment target in newly diagnosed systemic lupus erythematosus, 10 most important contemporary challenges in the management of SLE, Measurement of systemic lupus erythematosus activity in clinical research, Definition, incidence, and clinical description of flare in systemic lupus erythematosus. Associations between physicians' global assessment of disease activity Federal government websites often end in .gov or .mil. Please check for further notifications by email. et al. sharing sensitive information, make sure youre on a federal Epub 2014 Apr 11. , Gordon C , Bonithon-Kopp C , Flower C Touma Z The literature search identified 93 articles, and 12 additional articles were retrieved from the reference list of those publications. Published by Oxford University Press on behalf of the British Society for Rheumatology. Some may be a consequence of therapy and others may be . , Goldsmith CH physician global assessment (pga) - Assesschild , Tanangunan R Thanks to this feature, the PGA was included in composite indices with the aim of rating manifestations not included in glossary-based instruments such as the SLEDAI and BILAG [3] or for which a threshold has been defined (cytopenia). Bookshelf , Piette EW 2014 Sep-Oct;10(5):309-20. doi: 10.1016/j.reuma.2014.01.012. , Pilkington C Five studies have demonstrated good ICC values for reliability (all >0.60 and ranging up to 0.97). It is therefore desirable to use the PGA along with other tools (typically the SLEDAI) or to include the PGA in a composite index (e.g. Observed and articulated management issues and responses.

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